The occurrence of hot flushes.
In our brain special group of cells called KNDy neurons that play a key role in controlling hormone levels and body temperature. These neurons are located in an area of the brain known as the hypothalamus and they work with hormones like estrogen to regulate several functions.
KNDy neurons help manage the release of a hormone called GnRH, which is important for reproductive health because it influences other hormones that affect the ovaries.
These neurons also have a role in regulating body heat, which is why they’re linked to the
hot flushes often experienced during menopause.
During menopause, as women transition with age, the usual way these neurons work can change.
They might not respond to estrogen as they did before, and their usual signaling might become
stronger or different.
This change is believed to contribute to the hot flushes many women experience during this time. By understanding how these neurons work, we can gain insights into managing menopausal symptoms better.
Learn more about how to best manage hot flushes at: https//menopause-and-you.com
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 1, January 2021, Pages 1–15, https://doi.org/10.1210/clinem/dgaa764